May 29, 2017
Note from Pastor Kevin Lea: After reading these two articles, I hope the reader will see the foolishness of Darwinian evolution. How can time and chance create the billions of very detailed genetic coding instructions necessary for the healthy growth and function of every living thing? The evidence is beyond contradiction that in the beginning God created life, and when men try to mess with it, bad things happen.
A new study has found that CRISPR gene-editing may have unintended genetic side effects (Credit: lightsource/Depositphotos)
It’s not hyperbolic to say that the CRISPR-Cas9 gene-editing technique has been a revolutionary breakthrough, allowing scientists the ability to quickly, easily and precisely edit sections of DNA. But questions over how precise the CRISPR tool is have been raised in a new study from Columbia University Medical Center, which shows this gene-editing technology can introduce hundreds of unintended mutations into the genome.
CRISPR has sparked a flurry of new avenues of research around the world, from targeting cancer to HIV, with the first human trials involving CRISPR-edited cells already underway in China and a US trial slated for 2018. But this new study urges caution moving forward, suggesting we are still yet to understand the greater genomic effects of the tool.
The team of scientists involved in the study had previously been working with the CRISPR tool to treat a serious eye disease called retinitis pigmentosa, which leads to blindness. They decided to examine the entire genome of the CRISPR-treated mice from their previous experiments, looking for any potential mutations, even those that altered just a single nucleotide.
Generally, when scientists are trying to identify whether a CRISPR edit has resulted in an off-target mutation or deletion they use computer algorithms to identify areas most likely to be affected and focus their attention on those.
“These predictive algorithms seem to do a good job when CRISPR is performed in cells or tissues in a dish,” says co-author of the study, Professor Alexander Bassuk, “but whole genome sequencing has not been employed to look for all off-target effects in living animals.”
In examining the entire genome from the CRISPR-treated mice, they found that the tool had successfully corrected the specific gene they were targeting, but it also potentially caused a great deal of other genetic changes. In two CRISPR-treated animals, more than 100 large gene deletions or insertions and over 1,500 single-nucleotide mutations were identified.
Most significantly, all of these identified mutations were not picked up by the general computer algorithms most researchers use to look at the off-target effects of CRISPR-editing. There were no obvious or
To read this article in its entirety, go to: http://newatlas.com/crispr-gene-editing-causes-mutations/49762/?li_source=LI&li_medium=default-widget
Researchers Test Self-Destructing Moth Pest in Cabbage Patch
By Mary Esch
May 29, 2017
ALBANY, N.Y. (AP) — Researchers in a New York cabbage patch are planning the first release on American soil of insects genetically engineered to die before they can reproduce.
It’s a pesticide-free attempt to control invasive diamondback moths, a voracious consumer of cabbage, broccoli and other cruciferous crops that’s notorious for its ability to shrug off every new poison in the agricultural arsenal.
“It costs $4-5 billion a year globally to manage this pest,” said Anthony Shelton, a Cornell University researcher who’s been studying the species for 40 years. “If you can manage it without using insecticides that can affect pollinators and other non-target organisms, that’s a real advantage.”
Shelton is doing field tests of gene-altered moths at Cornell’s Agricultural Experiment Station in Geneva, 160 miles west of Albany. Those experiments began in 2015, but until now were restricted to net-covered plots to keep the moths from straying. Now, he’s awaiting a permit from the
To read this article in its entirety, go to: http://hosted.ap.org/dynamic/stories/U/US_GENE_ALTERED_MOTHS?SITE=AP&SECTION=HOME&TEMPLATE=DEFAULT&CTIME=2017-05-29-09-57-09